Repeats, longevity and the sources of mtDNA deletions: evidence from †̃deletional spectraâ€TM
نویسندگان
چکیده
1 Harvard Medical School/Beth Israel Deaconess Medical Center, Boston, MA USA 2 Russian Academy of Sciences Institute for Information Transmission Problems and Moscow State University, Moscow, Russia 3 Draper Laboratory, Cambridge MA, USA 4 Genome Institute of Singapore, Singapore 5 The Institute of Ageing and Health and Newcastle University, Newcastle upon Tyne, UK 6 Department of Epileptology and Life&Brain Center, University Bonn Medical Center, Bonn, Germany 7 Hunan University, Changsha, Hunan, People’s Republic of China Update
منابع مشابه
Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'.
Perfect direct repeats and, in particular, the prominent 13 bp repeat, are thought to cause mitochondrial DNA (mtDNA) deletions, which have been associated with the aging process. Accordingly, individuals lacking the 13 bp repeat are highly prevalent among centenarians and overall number of perfect repeats in mammalian mitochondrial genomes negatively correlates with species' longevity. However...
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تاریخ انتشار 2010